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KMID : 1123920060200020404
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 2 p.404 ~ p.409
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Anti Allergic Effects of Cimicifuga Racemosa on Allergic Models
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Jung Heung-Sik
Kang Kyung-Hwa
Choi Yung-Hyun
Choi Byung-Tae
Lee Yong-Tae
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Abstract
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Cimicifuga racemosa (Black cohosh) has been used as therapeutics for pain and inflammation in Korean folk medicine. The potential effects of cimicifuga racemosa extract on mast cell dependent allergy reaction, however, have not been well elucidated yet. In the present study, we investigated the effect of cimicifuga racemosa extract on the allergy reaction using mast cell dependent in vivo and in vitro models. The oral administration of cimicifuga racemosa extract showed inhibitory potential on the compound 48/80 induced active systemic anaphylactic shock. cimicifuga racemosa extract also significantly inhibited the anti DNP IgE induced passive cutaneous anaphylaxis (PCA) reaction and acetic acid induced vascular permeability. In addition, cimicifuga racemosa extract inhibited the beta hexosaminidase release and TNF alpha and IL 4 mRNA induction by DNP HSA in rat leukemia mast cells, RBL 2H3. but cimicifuga racemosa extract didn’t affected to RBL 2H3 cell viability. These results demonstrated that cimicifuga racemosa extract has an anti allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.
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KEYWORD
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Cimicifuga racemosa, allergy, compound 48/80, anaphylaxis, cytokine
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